Senior Research Scientist

  • Senior Research Scientist

    **Looking for Ontario based scientists looking to relocate to Montreal**


    Our client is seeking an experienced scientist to assume a hands-on role as part of a scientific team responsible for assessing the in vivo pharmacology and efficacy of novel pre-clinical anticancer compounds.  The scientist will be involved in evaluating drug combinations with targeted agents and with immuno-oncology therapeutics, establishing detailed PK/PD relationships, therapeutic window and performing mechanism-of-action studies.

    RESPONSIBILITIES
    • The level of position responsibilities will be adjusted according to the candidate’s background and experience level;
    • To identify and implement clinically relevant rodent models in which to evaluate the in vivo efficacy of novel anticancer compounds;
    • To research, identify and develop relevant pharmacodynamic markers to monitor compound target engagement in vivo;
    • To develop pharmacodynamic assays to quantitatively track target engagement in blood and/or tumor tissues by western blot, ELISA, bead proximity, IHC, qRT-PCR, FACS or other means;
    • To harvest tumor and tissue samples from treated animals and establish PK/PD and toxicity relationships in vivo.To process blood and tissue samples for monitoring PD markers, hematological and tissue toxicities;
    • To conduct drug PK/PD modeling to optimize dose/scheduling and therapeutic window;
    • To communicate results at project team meetings and be involved in the coordination and preparation of presentations, reports and manuscripts for publication in peer-reviewed journals;
    • To maintain detailed laboratory notes and protocols;
    • The successful candidate may be required to work non-standard hours from time to time, including occasional weekend and statutory holidays as required by on-going experiments.

    QUALIFICATIONS
    • MSc or PhD in biological sciences and minimum of 3 years relevant experience;
    • Experience in oncology, DNA repair and/or chromatin remodelling is essential;
    • A strong background in cell biology and quantitative cell-based assay development using various modalities including FACS is essential;
    • Diverse experience in cell and molecular biology techniques to monitor PK/PD relationships is essential;
    • Experience in pre-clinical drug discovery in an industrial setting is an asset;
    • Experience in small animal handling, preferentially in carrying out pre-clinical rodent oncology models is an asset;
    • Experience with pharmacodynamic modelling software is an asset;
    • Ability to communicate in an open, clear, timely and consistent manner;
    • Outstanding organizational skills (lab book, experimental design, documentation etc.);
    • Ability to handle multiple projects and utilize judgement to prioritize tasks;
    • Ability to contribute as a team member in a dynamic, fast-paced biotech environment.

    If you are interested in this opportunity, please submit your resume using the "Apply Now" button or send directly to Bryan Forrest at bforrest@locksearchgroup.com


    Please note only qualified candidates will be contacted.